diff --git a/lib/tokenize.cpp b/lib/tokenize.cpp
index 75f28fc62..567773cb5 100644
--- a/lib/tokenize.cpp
+++ b/lib/tokenize.cpp
@@ -7912,12 +7912,17 @@ void Tokenizer::simplifyComma()
 
         if (!tok)
             syntaxError(nullptr); // invalid code like in #4195
-        if (Token::Match(tok, "(|[") ||
-            (tok->str() == "{" && tok->previous() && tok->previous()->str() == "=")) {
+
+        if (Token::Match(tok, "(|[") || Token::Match(tok->previous(), "%name%|= {")) {
             tok = tok->link();
             continue;
         }
 
+        if (Token::simpleMatch(tok, "= (") && Token::simpleMatch(tok->linkAt(1), ") {")) {
+            tok = tok->linkAt(1)->linkAt(1);
+            continue;
+        }
+
         // Skip unhandled template specifiers..
         if (tok->link() && tok->str() == "<")
             tok = tok->link();
diff --git a/test/testsimplifytokens.cpp b/test/testsimplifytokens.cpp
index d79dd89c2..fd5691ab9 100644
--- a/test/testsimplifytokens.cpp
+++ b/test/testsimplifytokens.cpp
@@ -1966,6 +1966,12 @@ private:
                                      "}";
             ASSERT_EQUALS(expected, tok(code));
         }
+
+        {
+            const char code[]     = "tr = (struct reg){ .a = (1), .c = (2) };";
+            const char expected[] = "tr = ( struct reg ) { . a = 1 , . c = 2 } ;";
+            ASSERT_EQUALS(expected, tok(code));
+        }
     }
 
     void simplifyConditionOperator() {