diff --git a/lib/tokenize.cpp b/lib/tokenize.cpp
index 38d8a9897..ea3367b0b 100644
--- a/lib/tokenize.cpp
+++ b/lib/tokenize.cpp
@@ -234,6 +234,7 @@ bool Tokenizer::duplicateTypedef(Token **tokPtr, const Token *name, const Token
             } else {
                 // look backwards
                 if (Token::Match(tok->previous(), "typedef|}|>") ||
+                    (end->str() == ";" && tok->previous()->str() == ",") ||
                     (tok->previous()->str() == "*" && tok->next()->str() != "(") ||
                     (Token::Match(tok->previous(), "%type%") &&
                      (!Token::Match(tok->previous(), "return|new|const|friend|public|private|protected|throw|extern") &&
diff --git a/test/testsimplifytokens.cpp b/test/testsimplifytokens.cpp
index 56d2861f5..5619f4c1f 100644
--- a/test/testsimplifytokens.cpp
+++ b/test/testsimplifytokens.cpp
@@ -308,6 +308,8 @@ private:
         TEST_CASE(simplifyTypedefFunction7);
         TEST_CASE(simplifyTypedefFunction8);
 
+        TEST_CASE(simplifyTypedefShadow);  // #4445 - shadow variable
+
         TEST_CASE(simplifyOperator1);
 
         TEST_CASE(reverseArraySyntax)
@@ -6573,6 +6575,15 @@ private:
         TODO_ASSERT_EQUALS("", "[test.cpp:2]: (debug) Function::addArguments found argument 'int' with varid 0.\n", errout.str());  // make sure that there is no internal error
     }
 
+    void simplifyTypedefShadow() { // shadow variable (#4445)
+        const char code[] = "typedef struct { int x; } xyz;;\n"
+                            "void f(){\n"
+                            "    int abc, xyz;\n" // <- shadow variable
+                            "}\n";
+        ASSERT_EQUALS("struct xyz { int x ; } ; void f ( ) { int abc ; int xyz ; }",
+                      tok(code,false));
+    }
+
     void simplifyOperator1() {
         // #3237 - error merging namespaces with operators
         const char code[] = "class c {\n"