diff --git a/src/h2load.cc b/src/h2load.cc
index e7f368c8..6a58d1ae 100644
--- a/src/h2load.cc
+++ b/src/h2load.cc
@@ -2845,19 +2845,26 @@ int main(int argc, char **argv) {
     exit(EXIT_FAILURE);
   }
 
-#if OPENSSL_1_1_1_API
+#if OPENSSL_1_1_1_API && !defined(OPENSSL_IS_BORINGSSL)
   if (SSL_CTX_set_ciphersuites(ssl_ctx, config.tls13_ciphers.c_str()) == 0) {
     std::cerr << "SSL_CTX_set_ciphersuites with " << config.tls13_ciphers
               << " failed: " << ERR_error_string(ERR_get_error(), nullptr)
               << std::endl;
     exit(EXIT_FAILURE);
   }
-#endif // OPENSSL_1_1_1_API
+#endif // OPENSSL_1_1_1_API && !defined(OPENSSL_IS_BORINGSSL)
 
+#if OPENSSL_1_1_1_API && !defined(OPENSSL_IS_BORINGSSL)
   if (SSL_CTX_set1_groups_list(ssl_ctx, config.groups.c_str()) != 1) {
     std::cerr << "SSL_CTX_set1_groups_list failed" << std::endl;
     exit(EXIT_FAILURE);
   }
+#else  // !(OPENSSL_1_1_1_API && !defined(OPENSSL_IS_BORINGSSL))
+  if (SSL_CTX_set1_curves_list(ssl_ctx, config.groups.c_str()) != 1) {
+    std::cerr << "SSL_CTX_set1_curves_list failed" << std::endl;
+    exit(EXIT_FAILURE);
+  }
+#endif // !(OPENSSL_1_1_1_API && !defined(OPENSSL_IS_BORINGSSL))
 
 #ifndef OPENSSL_NO_NEXTPROTONEG
   SSL_CTX_set_next_proto_select_cb(ssl_ctx, client_select_next_proto_cb,
diff --git a/src/shrpx_connection.cc b/src/shrpx_connection.cc
index d07314b6..fc108bbd 100644
--- a/src/shrpx_connection.cc
+++ b/src/shrpx_connection.cc
@@ -397,7 +397,7 @@ int Connection::tls_handshake() {
 
   ERR_clear_error();
 
-#if OPENSSL_1_1_1_API
+#if OPENSSL_1_1_1_API && !defined(OPENSSL_IS_BORINGSSL)
   if (!tls.server_handshake || tls.early_data_finish) {
     rv = SSL_do_handshake(tls.ssl);
   } else {
@@ -449,9 +449,9 @@ int Connection::tls_handshake() {
       }
     }
   }
-#else  // !OPENSSL_1_1_1_API
+#else  // !(OPENSSL_1_1_1_API && !defined(OPENSSL_IS_BORINGSSL))
   rv = SSL_do_handshake(tls.ssl);
-#endif // !OPENSSL_1_1_1_API
+#endif // !(OPENSSL_1_1_1_API && !defined(OPENSSL_IS_BORINGSSL))
 
   if (rv <= 0) {
     auto err = SSL_get_error(tls.ssl, rv);
@@ -698,7 +698,7 @@ ssize_t Connection::write_tls(const void *data, size_t len) {
 
   ERR_clear_error();
 
-#if OPENSSL_1_1_1_API
+#if OPENSSL_1_1_1_API && !defined(OPENSSL_IS_BORINGSSL)
   int rv;
   if (SSL_is_init_finished(tls.ssl)) {
     rv = SSL_write(tls.ssl, data, len);
@@ -710,9 +710,9 @@ ssize_t Connection::write_tls(const void *data, size_t len) {
       rv = nwrite;
     }
   }
-#else  // !OPENSSL_1_1_1_API
+#else  // !(OPENSSL_1_1_1_API && !defined(OPENSSL_IS_BORINGSSL))
   auto rv = SSL_write(tls.ssl, data, len);
-#endif // !OPENSSL_1_1_1_API
+#endif // !(OPENSSL_1_1_1_API && !defined(OPENSSL_IS_BORINGSSL))
 
   if (rv <= 0) {
     auto err = SSL_get_error(tls.ssl, rv);
@@ -772,7 +772,7 @@ ssize_t Connection::read_tls(void *data, size_t len) {
     tls.last_readlen = 0;
   }
 
-#if OPENSSL_1_1_1_API
+#if OPENSSL_1_1_1_API && !defined(OPENSSL_IS_BORINGSSL)
   if (!tls.early_data_finish) {
     // TLSv1.3 handshake is still going on.
     size_t nread;
@@ -811,7 +811,7 @@ ssize_t Connection::read_tls(void *data, size_t len) {
     }
     return nread;
   }
-#endif // OPENSSL_1_1_1_API
+#endif // OPENSSL_1_1_1_API && !defined(OPENSSL_IS_BORINGSSL)
 
   auto rv = SSL_read(tls.ssl, data, len);
 
diff --git a/src/shrpx_tls.cc b/src/shrpx_tls.cc
index a933b660..12539ad5 100644
--- a/src/shrpx_tls.cc
+++ b/src/shrpx_tls.cc
@@ -731,7 +731,8 @@ int quic_alpn_select_proto_cb(SSL *ssl, const unsigned char **out,
 #  endif // OPENSSL_VERSION_NUMBER >= 0x10002000L
 #endif   // ENABLE_HTTP3
 
-#if !LIBRESSL_IN_USE && OPENSSL_VERSION_NUMBER >= 0x10002000L
+#if !LIBRESSL_IN_USE && OPENSSL_VERSION_NUMBER >= 0x10002000L &&               \
+    !defined(OPENSSL_IS_BORINGSSL)
 
 #  ifndef TLSEXT_TYPE_signed_certificate_timestamp
 #    define TLSEXT_TYPE_signed_certificate_timestamp 18
@@ -821,7 +822,8 @@ int legacy_sct_parse_cb(SSL *ssl, unsigned int ext_type,
 } // namespace
 
 #  endif // !OPENSSL_1_1_1_API
-#endif   // !LIBRESSL_IN_USE && OPENSSL_VERSION_NUMBER >= 0x10002000L
+#endif   // !LIBRESSL_IN_USE && OPENSSL_VERSION_NUMBER >= 0x10002000L &&
+         // !defined(OPENSSL_IS_BORINGSSL)
 
 #ifndef OPENSSL_NO_PSK
 namespace {
@@ -931,14 +933,14 @@ SSL_CTX *create_ssl_context(const char *private_key_file, const char *cert_file,
       SSL_OP_NO_SESSION_RESUMPTION_ON_RENEGOTIATION | SSL_OP_SINGLE_ECDH_USE |
       SSL_OP_SINGLE_DH_USE |
       SSL_OP_CIPHER_SERVER_PREFERENCE
-#if OPENSSL_1_1_1_API
+#if OPENSSL_1_1_1_API && !defined(OPENSSL_IS_BORINGSSL)
       // The reason for disabling built-in anti-replay in OpenSSL is
       // that it only works if client gets back to the same server.
       // The freshness check described in
       // https://tools.ietf.org/html/rfc8446#section-8.3 is still
       // performed.
       | SSL_OP_NO_ANTI_REPLAY
-#endif // OPENSSL_1_1_1_API
+#endif // OPENSSL_1_1_1_API && !defined(OPENSSL_IS_BORINGSSL)
       ;
 
   auto config = mod_config();
@@ -969,13 +971,13 @@ SSL_CTX *create_ssl_context(const char *private_key_file, const char *cert_file,
     DIE();
   }
 
-#if OPENSSL_1_1_1_API
+#if OPENSSL_1_1_1_API && !defined(OPENSSL_IS_BORINGSSL)
   if (SSL_CTX_set_ciphersuites(ssl_ctx, tlsconf.tls13_ciphers.c_str()) == 0) {
     LOG(FATAL) << "SSL_CTX_set_ciphersuites " << tlsconf.tls13_ciphers
                << " failed: " << ERR_error_string(ERR_get_error(), nullptr);
     DIE();
   }
-#endif // OPENSSL_1_1_1_API
+#endif // OPENSSL_1_1_1_API && !defined(OPENSSL_IS_BORINGSSL)
 
 #ifndef OPENSSL_NO_EC
 #  if !LIBRESSL_LEGACY_API && OPENSSL_VERSION_NUMBER >= 0x10002000L
@@ -1172,13 +1174,13 @@ SSL_CTX *create_ssl_context(const char *private_key_file, const char *cert_file,
 #endif // !LIBRESSL_IN_USE && OPENSSL_VERSION_NUMBER >= 0x10002000L &&
        // !defined(OPENSSL_IS_BORINGSSL)
 
-#if OPENSSL_1_1_1_API
+#if OPENSSL_1_1_1_API && !defined(OPENSSL_IS_BORINGSSL)
   if (SSL_CTX_set_max_early_data(ssl_ctx, tlsconf.max_early_data) != 1) {
     LOG(FATAL) << "SSL_CTX_set_max_early_data failed: "
                << ERR_error_string(ERR_get_error(), nullptr);
     DIE();
   }
-#endif // OPENSSL_1_1_1_API
+#endif // OPENSSL_1_1_1_API && !defined(OPENSSL_IS_BORINGSSL)
 
 #ifndef OPENSSL_NO_PSK
   SSL_CTX_set_psk_server_callback(ssl_ctx, psk_server_cb);
@@ -1616,14 +1618,14 @@ SSL_CTX *create_ssl_client_context(
     DIE();
   }
 
-#if OPENSSL_1_1_1_API
+#if OPENSSL_1_1_1_API && !defined(OPENSSL_IS_BORINGSSL)
   if (SSL_CTX_set_ciphersuites(ssl_ctx, tlsconf.client.tls13_ciphers.c_str()) ==
       0) {
     LOG(FATAL) << "SSL_CTX_set_ciphersuites " << tlsconf.client.tls13_ciphers
                << " failed: " << ERR_error_string(ERR_get_error(), nullptr);
     DIE();
   }
-#endif // OPENSSL_1_1_1_API
+#endif // OPENSSL_1_1_1_API && !defined(OPENSSL_IS_BORINGSSL)
 
   SSL_CTX_set_mode(ssl_ctx, SSL_MODE_RELEASE_BUFFERS);
 
@@ -2625,7 +2627,7 @@ namespace {
 int time_t_from_asn1_time(time_t &t, const ASN1_TIME *at) {
   int rv;
 
-#if OPENSSL_1_1_1_API
+#if OPENSSL_1_1_1_API && !defined(OPENSSL_IS_BORINGSSL)
   struct tm tm;
   rv = ASN1_TIME_to_tm(at, &tm);
   if (rv != 1) {
@@ -2633,7 +2635,7 @@ int time_t_from_asn1_time(time_t &t, const ASN1_TIME *at) {
   }
 
   t = nghttp2_timegm(&tm);
-#else // !OPENSSL_1_1_1_API
+#else // !(OPENSSL_1_1_1_API && !defined(OPENSSL_IS_BORINGSSL))
   auto b = BIO_new(BIO_s_mem());
   if (!b) {
     return -1;
@@ -2659,7 +2661,7 @@ int time_t_from_asn1_time(time_t &t, const ASN1_TIME *at) {
   }
 
   t = tt;
-#endif // !OPENSSL_1_1_1_API
+#endif // !(OPENSSL_1_1_1_API && !defined(OPENSSL_IS_BORINGSSL))
 
   return 0;
 }
diff --git a/src/tls.h b/src/tls.h
index ee8a5d7f..8b785ffc 100644
--- a/src/tls.h
+++ b/src/tls.h
@@ -57,11 +57,11 @@ constexpr char DEFAULT_CIPHER_LIST[] =
     "AES256-SHA384:ECDHE-ECDSA-AES128-SHA256:ECDHE-RSA-AES128-SHA256";
 
 constexpr char DEFAULT_TLS13_CIPHER_LIST[] =
-#if OPENSSL_1_1_1_API
+#if OPENSSL_1_1_1_API && !defined(OPENSSL_IS_BORINGSSL)
     TLS_DEFAULT_CIPHERSUITES
-#else  // !OPENSSL_1_1_1_API
+#else  // !(OPENSSL_1_1_1_API && !defined(OPENSSL_IS_BORINGSSL))
     ""
-#endif // !OPENSSL_1_1_1_API
+#endif // !(OPENSSL_1_1_1_API && !defined(OPENSSL_IS_BORINGSSL))
     ;
 
 constexpr auto NGHTTP2_TLS_MIN_VERSION = TLS1_VERSION;