diff --git a/examples/client.c b/examples/client.c
index bb6f1815..5b759324 100644
--- a/examples/client.c
+++ b/examples/client.c
@@ -375,7 +375,9 @@ static void init_ssl_ctx(SSL_CTX *ssl_ctx) {
   SSL_CTX_set_mode(ssl_ctx, SSL_MODE_AUTO_RETRY);
   SSL_CTX_set_mode(ssl_ctx, SSL_MODE_RELEASE_BUFFERS);
   /* Set NPN callback */
+#ifndef OPENSSL_NO_NEXTPROTONEG
   SSL_CTX_set_next_proto_select_cb(ssl_ctx, select_next_proto_cb, NULL);
+#endif
 }
 
 static void ssl_handshake(SSL *ssl, int fd) {
diff --git a/examples/libevent-client.c b/examples/libevent-client.c
index bfee21ea..e76d7fa0 100644
--- a/examples/libevent-client.c
+++ b/examples/libevent-client.c
@@ -335,7 +335,9 @@ static SSL_CTX *create_ssl_ctx(void) {
                       SSL_OP_ALL | SSL_OP_NO_SSLv2 | SSL_OP_NO_SSLv3 |
                           SSL_OP_NO_COMPRESSION |
                           SSL_OP_NO_SESSION_RESUMPTION_ON_RENEGOTIATION);
+#ifndef OPENSSL_NO_NEXTPROTONEG
   SSL_CTX_set_next_proto_select_cb(ssl_ctx, select_next_proto_cb, NULL);
+#endif
 
 #if OPENSSL_VERSION_NUMBER >= 0x10002000L
   SSL_CTX_set_alpn_protos(ssl_ctx, (const unsigned char *)"\x02h2", 3);
@@ -504,7 +506,9 @@ static void eventcb(struct bufferevent *bev, short events, void *ptr) {
 
     ssl = bufferevent_openssl_get_ssl(session_data->bev);
 
+#ifndef OPENSSL_NO_NEXTPROTONEG
     SSL_get0_next_proto_negotiated(ssl, &alpn, &alpnlen);
+#endif
 #if OPENSSL_VERSION_NUMBER >= 0x10002000L
     if (alpn == NULL) {
       SSL_get0_alpn_selected(ssl, &alpn, &alpnlen);
diff --git a/examples/libevent-server.c b/examples/libevent-server.c
index 403d2dd4..f9e9b50e 100644
--- a/examples/libevent-server.c
+++ b/examples/libevent-server.c
@@ -172,7 +172,9 @@ static SSL_CTX *create_ssl_ctx(const char *key_file, const char *cert_file) {
          NGHTTP2_PROTO_VERSION_ID_LEN);
   next_proto_list_len = 1 + NGHTTP2_PROTO_VERSION_ID_LEN;
 
+#ifndef OPENSSL_NO_NEXTPROTONEG
   SSL_CTX_set_next_protos_advertised_cb(ssl_ctx, next_proto_cb, NULL);
+#endif
 
 #if OPENSSL_VERSION_NUMBER >= 0x10002000L
   SSL_CTX_set_alpn_select_cb(ssl_ctx, alpn_select_proto_cb, NULL);
@@ -690,7 +692,9 @@ static void eventcb(struct bufferevent *bev, short events, void *ptr) {
 
     ssl = bufferevent_openssl_get_ssl(session_data->bev);
 
+#ifndef OPENSSL_NO_NEXTPROTONEG
     SSL_get0_next_proto_negotiated(ssl, &alpn, &alpnlen);
+#endif
 #if OPENSSL_VERSION_NUMBER >= 0x10002000L
     if (alpn == NULL) {
       SSL_get0_alpn_selected(ssl, &alpn, &alpnlen);
diff --git a/src/HttpServer.cc b/src/HttpServer.cc
index b3e35ef7..4e43567c 100644
--- a/src/HttpServer.cc
+++ b/src/HttpServer.cc
@@ -888,7 +888,9 @@ int Http2Handler::verify_npn_result() {
   const unsigned char *next_proto = nullptr;
   unsigned int next_proto_len;
   // Check the negotiated protocol in NPN or ALPN
+#ifndef OPENSSL_NO_NEXTPROTONEG
   SSL_get0_next_proto_negotiated(ssl_, &next_proto, &next_proto_len);
+#endif
   for (int i = 0; i < 2; ++i) {
     if (next_proto) {
       auto proto = StringRef{next_proto, next_proto_len};
@@ -2205,7 +2207,9 @@ int HttpServer::run() {
 
     next_proto = util::get_default_alpn();
 
+#ifndef OPENSSL_NO_NEXTPROTONEG
     SSL_CTX_set_next_protos_advertised_cb(ssl_ctx, next_proto_cb, &next_proto);
+#endif
 #if OPENSSL_VERSION_NUMBER >= 0x10002000L
     // ALPN selection callback
     SSL_CTX_set_alpn_select_cb(ssl_ctx, alpn_select_proto_cb, this);
diff --git a/src/asio_common.cc b/src/asio_common.cc
index 590e931f..6aa46abc 100644
--- a/src/asio_common.cc
+++ b/src/asio_common.cc
@@ -177,7 +177,9 @@ bool tls_h2_negotiated(ssl_socket &socket) {
   const unsigned char *next_proto = nullptr;
   unsigned int next_proto_len = 0;
 
+#ifndef OPENSSL_NO_NEXTPROTONEG
   SSL_get0_next_proto_negotiated(ssl, &next_proto, &next_proto_len);
+#endif
 #if OPENSSL_VERSION_NUMBER >= 0x10002000L
   if (next_proto == nullptr) {
     SSL_get0_alpn_selected(ssl, &next_proto, &next_proto_len);
diff --git a/src/h2load.cc b/src/h2load.cc
index 5f7789c9..7df9c52f 100644
--- a/src/h2load.cc
+++ b/src/h2load.cc
@@ -857,7 +857,9 @@ int Client::connection_made() {
     const unsigned char *next_proto = nullptr;
     unsigned int next_proto_len;
 
+#ifndef OPENSSL_NO_NEXTPROTONEG
     SSL_get0_next_proto_negotiated(ssl, &next_proto, &next_proto_len);
+#endif
 #if OPENSSL_VERSION_NUMBER >= 0x10002000L
     if (next_proto == nullptr) {
       SSL_get0_alpn_selected(ssl, &next_proto, &next_proto_len);
@@ -2399,8 +2401,10 @@ int main(int argc, char **argv) {
     exit(EXIT_FAILURE);
   }
 
+#ifndef OPENSSL_NO_NEXTPROTONEG
   SSL_CTX_set_next_proto_select_cb(ssl_ctx, client_select_next_proto_cb,
                                    nullptr);
+#endif
 
 #if OPENSSL_VERSION_NUMBER >= 0x10002000L
   std::vector<unsigned char> proto_list;
diff --git a/src/nghttp.cc b/src/nghttp.cc
index 7c29b3ce..f6cc0035 100644
--- a/src/nghttp.cc
+++ b/src/nghttp.cc
@@ -1095,7 +1095,9 @@ int HttpClient::connection_made() {
     // Check NPN or ALPN result
     const unsigned char *next_proto = nullptr;
     unsigned int next_proto_len;
+#ifndef OPENSSL_NO_NEXTPROTONEG
     SSL_get0_next_proto_negotiated(ssl, &next_proto, &next_proto_len);
+#endif
     for (int i = 0; i < 2; ++i) {
       if (next_proto) {
         auto proto = StringRef{next_proto, next_proto_len};
@@ -2308,8 +2310,10 @@ int communicate(
         goto fin;
       }
     }
+#ifndef OPENSSL_NO_NEXTPROTONEG
     SSL_CTX_set_next_proto_select_cb(ssl_ctx, client_select_next_proto_cb,
                                      nullptr);
+#endif
 
 #if OPENSSL_VERSION_NUMBER >= 0x10002000L
     auto proto_list = util::get_default_alpn();
diff --git a/src/shrpx_client_handler.cc b/src/shrpx_client_handler.cc
index 21430dd4..491b2e35 100644
--- a/src/shrpx_client_handler.cc
+++ b/src/shrpx_client_handler.cc
@@ -549,7 +549,9 @@ int ClientHandler::validate_next_proto() {
   // First set callback for catch all cases
   on_read_ = &ClientHandler::upstream_read;
 
+#ifndef OPENSSL_NO_NEXTPROTONEG
   SSL_get0_next_proto_negotiated(conn_.tls.ssl, &next_proto, &next_proto_len);
+#endif
 #if OPENSSL_VERSION_NUMBER >= 0x10002000L
   if (next_proto == nullptr) {
     SSL_get0_alpn_selected(conn_.tls.ssl, &next_proto, &next_proto_len);
diff --git a/src/shrpx_connection.cc b/src/shrpx_connection.cc
index 06ad9581..3ea37b5a 100644
--- a/src/shrpx_connection.cc
+++ b/src/shrpx_connection.cc
@@ -523,7 +523,9 @@ int Connection::check_http2_requirement() {
   const unsigned char *next_proto = nullptr;
   unsigned int next_proto_len;
 
+#ifndef OPENSSL_NO_NEXTPROTONEG
   SSL_get0_next_proto_negotiated(tls.ssl, &next_proto, &next_proto_len);
+#endif
 #if OPENSSL_VERSION_NUMBER >= 0x10002000L
   if (next_proto == nullptr) {
     SSL_get0_alpn_selected(tls.ssl, &next_proto, &next_proto_len);
diff --git a/src/shrpx_http2_session.cc b/src/shrpx_http2_session.cc
index 61c97caa..c2deae04 100644
--- a/src/shrpx_http2_session.cc
+++ b/src/shrpx_http2_session.cc
@@ -1649,7 +1649,9 @@ int Http2Session::connection_made() {
     const unsigned char *next_proto = nullptr;
     unsigned int next_proto_len = 0;
 
+#ifndef OPENSSL_NO_NEXTPROTONEG
     SSL_get0_next_proto_negotiated(conn_.tls.ssl, &next_proto, &next_proto_len);
+#endif
 #if OPENSSL_VERSION_NUMBER >= 0x10002000L
     if (!next_proto) {
       SSL_get0_alpn_selected(conn_.tls.ssl, &next_proto, &next_proto_len);
diff --git a/src/shrpx_live_check.cc b/src/shrpx_live_check.cc
index 863ffa51..07ad811e 100644
--- a/src/shrpx_live_check.cc
+++ b/src/shrpx_live_check.cc
@@ -406,7 +406,9 @@ int LiveCheck::tls_handshake() {
   const unsigned char *next_proto = nullptr;
   unsigned int next_proto_len = 0;
 
+#ifndef OPENSSL_NO_NEXTPROTONEG
   SSL_get0_next_proto_negotiated(conn_.tls.ssl, &next_proto, &next_proto_len);
+#endif
 #if OPENSSL_VERSION_NUMBER >= 0x10002000L
   if (next_proto == nullptr) {
     SSL_get0_alpn_selected(conn_.tls.ssl, &next_proto, &next_proto_len);
diff --git a/src/shrpx_tls.cc b/src/shrpx_tls.cc
index 87ca9285..6e8d808a 100644
--- a/src/shrpx_tls.cc
+++ b/src/shrpx_tls.cc
@@ -923,7 +923,9 @@ SSL_CTX *create_ssl_context(const char *private_key_file, const char *cert_file,
 #endif // OPENSSL_IS_BORINGSSL
 
   // NPN advertisement
+#ifndef OPENSSL_NO_NEXTPROTONEG
   SSL_CTX_set_next_protos_advertised_cb(ssl_ctx, next_proto_cb, nullptr);
+#endif
 #if OPENSSL_VERSION_NUMBER >= 0x10002000L
   // ALPN selection callback
   SSL_CTX_set_alpn_select_cb(ssl_ctx, alpn_select_proto_cb, nullptr);
@@ -1118,7 +1120,9 @@ SSL_CTX *create_ssl_client_context(
 
   // NPN selection callback.  This is required to set SSL_CTX because
   // OpenSSL does not offer SSL_set_next_proto_select_cb.
+#ifndef OPENSSL_NO_NEXTPROTONEG
   SSL_CTX_set_next_proto_select_cb(ssl_ctx, next_proto_select_cb, nullptr);
+#endif
 
   return ssl_ctx;
 }