diff --git a/src/Makefile.am b/src/Makefile.am
index 7f1cabe7..01701838 100644
--- a/src/Makefile.am
+++ b/src/Makefile.am
@@ -226,6 +226,7 @@ lib_LTLIBRARIES = libnghttp2_asio.la
 libnghttp2_asio_la_SOURCES = \
 	util.cc util.h http2.cc http2.h \
 	ssl.cc ssl.h \
+	ssl_compat.h \
 	timegm.c timegm.h \
 	asio_common.cc asio_common.h \
 	asio_io_service_pool.cc asio_io_service_pool.h \
diff --git a/src/shrpx.cc b/src/shrpx.cc
index cd655f8c..0534d739 100644
--- a/src/shrpx.cc
+++ b/src/shrpx.cc
@@ -81,6 +81,7 @@
 #include "shrpx_worker_process.h"
 #include "shrpx_process.h"
 #include "shrpx_signal.h"
+#include "shrpx_connection.h"
 #include "util.h"
 #include "app_helper.h"
 #include "ssl.h"
@@ -2073,6 +2074,8 @@ void process_options(int argc, char **argv,
 
   tlsconf.alpn_prefs = ssl::set_alpn_prefs(tlsconf.npn_list);
 
+  tlsconf.bio_method = create_bio_method();
+
   auto &listenerconf = mod_config()->conn.listener;
   auto &upstreamconf = mod_config()->conn.upstream;
   auto &downstreamconf = mod_config()->conn.downstream;
diff --git a/src/shrpx_config.h b/src/shrpx_config.h
index 09471d21..f801a0ea 100644
--- a/src/shrpx_config.h
+++ b/src/shrpx_config.h
@@ -463,6 +463,7 @@ struct TLSConfig {
   std::vector<std::string> npn_list;
   // list of supported SSL/TLS protocol strings.
   std::vector<std::string> tls_proto_list;
+  BIO_METHOD *bio_method;
   // Bit mask to disable SSL/TLS protocol versions.  This will be
   // passed to SSL_CTX_set_options().
   long int tls_proto_mask;
diff --git a/src/shrpx_connection.cc b/src/shrpx_connection.cc
index 428d98c4..95e1c320 100644
--- a/src/shrpx_connection.cc
+++ b/src/shrpx_connection.cc
@@ -36,10 +36,20 @@
 #include "shrpx_memcached_request.h"
 #include "memchunk.h"
 #include "util.h"
+#include "ssl_compat.h"
 
 using namespace nghttp2;
 
 namespace shrpx {
+
+#if !OPENSSL_101_API
+
+void *BIO_get_data(BIO *bio) { return bio->ptr; }
+void BIO_set_data(BIO *bio, void *ptr) { bio->ptr = ptr; }
+void BIO_set_init(BIO *bio, int init) { bio->init = init; }
+
+#endif // !OPENSSL_101_API
+
 Connection::Connection(struct ev_loop *loop, int fd, SSL *ssl,
                        MemchunkPool *mcpool, ev_tstamp write_timeout,
                        ev_tstamp read_timeout,
@@ -140,7 +150,7 @@ int shrpx_bio_write(BIO *b, const char *buf, int len) {
     return 0;
   }
 
-  auto conn = static_cast<Connection *>(b->ptr);
+  auto conn = static_cast<Connection *>(BIO_get_data(b));
   auto &wbuf = conn->tls.wbuf;
 
   BIO_clear_retry_flags(b);
@@ -181,7 +191,7 @@ int shrpx_bio_read(BIO *b, char *buf, int len) {
     return 0;
   }
 
-  auto conn = static_cast<Connection *>(b->ptr);
+  auto conn = static_cast<Connection *>(BIO_get_data(b));
   auto &rbuf = conn->tls.rbuf;
 
   BIO_clear_retry_flags(b);
@@ -230,10 +240,14 @@ long shrpx_bio_ctrl(BIO *b, int cmd, long num, void *ptr) {
 
 namespace {
 int shrpx_bio_create(BIO *b) {
+#if OPENSSL_101_API
+  BIO_set_init(b, 1);
+#else  // !OPENSSL_101_API
   b->init = 1;
   b->num = 0;
   b->ptr = nullptr;
   b->flags = 0;
+#endif // !OPENSSL_101_API
   return 1;
 }
 } // namespace
@@ -244,26 +258,55 @@ int shrpx_bio_destroy(BIO *b) {
     return 0;
   }
 
+#if !OPENSSL_101_API
   b->ptr = nullptr;
   b->init = 0;
   b->flags = 0;
+#endif // !OPENSSL_101_API
 
   return 1;
 }
 } // namespace
 
-namespace {
-BIO_METHOD shrpx_bio_method = {
-    BIO_TYPE_FD,    "nghttpx-bio",    shrpx_bio_write,
-    shrpx_bio_read, shrpx_bio_puts,   shrpx_bio_gets,
-    shrpx_bio_ctrl, shrpx_bio_create, shrpx_bio_destroy,
-};
-} // namespace
+#if OPENSSL_101_API
+
+BIO_METHOD *create_bio_method() {
+  auto meth = BIO_meth_new(BIO_TYPE_FD, "nghttpx-bio");
+  BIO_meth_set_write(meth, shrpx_bio_write);
+  BIO_meth_set_read(meth, shrpx_bio_read);
+  BIO_meth_set_puts(meth, shrpx_bio_puts);
+  BIO_meth_set_gets(meth, shrpx_bio_gets);
+  BIO_meth_set_ctrl(meth, shrpx_bio_ctrl);
+  BIO_meth_set_create(meth, shrpx_bio_create);
+  BIO_meth_set_destroy(meth, shrpx_bio_destroy);
+
+  return meth;
+}
+
+void delete_bio_method(BIO_METHOD *bio_method) { BIO_meth_free(bio_method); }
+
+#else // !OPENSSL_101_API
+
+BIO_METHOD *create_bio_method() {
+  static BIO_METHOD shrpx_bio_method = {
+      BIO_TYPE_FD,    "nghttpx-bio",    shrpx_bio_write,
+      shrpx_bio_read, shrpx_bio_puts,   shrpx_bio_gets,
+      shrpx_bio_ctrl, shrpx_bio_create, shrpx_bio_destroy,
+  };
+
+  return &shrpx_bio_method;
+}
+
+void delete_bio_method(BIO_METHOD *bio_method) {}
+
+#endif // !OPENSSL_101_API
 
 void Connection::set_ssl(SSL *ssl) {
   tls.ssl = ssl;
-  auto bio = BIO_new(&shrpx_bio_method);
-  bio->ptr = this;
+
+  auto &tlsconf = get_config()->tls;
+  auto bio = BIO_new(tlsconf.bio_method);
+  BIO_set_data(bio, this);
   SSL_set_bio(tls.ssl, bio, bio);
   SSL_set_app_data(tls.ssl, this);
 }
diff --git a/src/shrpx_connection.h b/src/shrpx_connection.h
index 71ba33f4..a361e15e 100644
--- a/src/shrpx_connection.h
+++ b/src/shrpx_connection.h
@@ -139,6 +139,15 @@ struct Connection {
   shrpx_proto proto;
 };
 
+// Creates BIO_method shared by all SSL objects.  If nghttp2 is built
+// with OpenSSL < 1.1.0, this returns statically allocated object.
+// Otherwise, it returns new BIO_METHOD object every time.
+BIO_METHOD *create_bio_method();
+
+// Deletes given |bio_method|.  If nghttp2 is built with OpenSSL <
+// 1.1.0, this function is noop.
+void delete_bio_method(BIO_METHOD *bio_method);
+
 } // namespace shrpx
 
 #endif // SHRPX_CONNECTION_H
diff --git a/src/shrpx_ssl.cc b/src/shrpx_ssl.cc
index 5feac51d..f500d446 100644
--- a/src/shrpx_ssl.cc
+++ b/src/shrpx_ssl.cc
@@ -61,6 +61,7 @@
 #include "util.h"
 #include "ssl.h"
 #include "template.h"
+#include "ssl_compat.h"
 
 using namespace nghttp2;
 
@@ -243,8 +244,13 @@ int tls_session_new_cb(SSL *ssl, SSL_SESSION *session) {
 } // namespace
 
 namespace {
-SSL_SESSION *tls_session_get_cb(SSL *ssl, unsigned char *id, int idlen,
-                                int *copy) {
+SSL_SESSION *tls_session_get_cb(SSL *ssl,
+#if OPENSSL_101_API
+                                const unsigned char *id,
+#else  // !OPENSSL_101_API
+                                unsigned char *id,
+#endif // !OPENSSL_101_API
+                                int idlen, int *copy) {
   auto conn = static_cast<Connection *>(SSL_get_app_data(ssl));
   auto handler = static_cast<ClientHandler *>(conn->data);
   auto worker = handler->get_worker();
diff --git a/src/ssl.cc b/src/ssl.cc
index 8d8cd782..0dc34ff7 100644
--- a/src/ssl.cc
+++ b/src/ssl.cc
@@ -32,6 +32,8 @@
 #include <openssl/crypto.h>
 #include <openssl/conf.h>
 
+#include "ssl_compat.h"
+
 namespace nghttp2 {
 
 namespace ssl {
@@ -52,6 +54,14 @@ const char *const DEFAULT_CIPHER_LIST =
     "SHA256:AES256-GCM-SHA384:AES128-SHA256:AES256-SHA256:AES128-SHA:AES256-"
     "SHA:DES-CBC3-SHA:!DSS";
 
+#if OPENSSL_101_API
+
+// CRYPTO_LOCK is deprecated as of OpenSSL 1.1.0
+LibsslGlobalLock::LibsslGlobalLock() {}
+LibsslGlobalLock::~LibsslGlobalLock() {}
+
+#else // !OPENSSL_101_API
+
 namespace {
 std::vector<std::mutex> ssl_global_locks;
 } // namespace
@@ -81,6 +91,8 @@ LibsslGlobalLock::LibsslGlobalLock() {
 
 LibsslGlobalLock::~LibsslGlobalLock() { ssl_global_locks.clear(); }
 
+#endif // !OPENSSL_101_API
+
 const char *get_tls_protocol(SSL *ssl) {
   switch (SSL_version(ssl)) {
   case SSL2_VERSION:
@@ -152,9 +164,12 @@ bool check_http2_requirement(SSL *ssl) {
 }
 
 void libssl_init() {
-#ifndef OPENSSL_IS_BORINGSSL
+// OPENSSL_config() is not available in BoringSSL.  It is also
+// deprecated as of OpenSSL 1.1.0.
+#if !defined(OPENSSL_IS_BORINGSSL) && !OPENSSL_101_API
   OPENSSL_config(nullptr);
-#endif // OPENSSL_IS_BORINGSSL
+#endif // !defined(OPENSSL_IS_BORINGSSL) && !OPENSSL_101_API
+
   SSL_load_error_strings();
   SSL_library_init();
   OpenSSL_add_all_algorithms();
diff --git a/src/ssl_compat.h b/src/ssl_compat.h
new file mode 100644
index 00000000..4b015624
--- /dev/null
+++ b/src/ssl_compat.h
@@ -0,0 +1,30 @@
+/*
+ * nghttp2 - HTTP/2 C Library
+ *
+ * Copyright (c) 2016 Tatsuhiro Tsujikawa
+ *
+ * Permission is hereby granted, free of charge, to any person obtaining
+ * a copy of this software and associated documentation files (the
+ * "Software"), to deal in the Software without restriction, including
+ * without limitation the rights to use, copy, modify, merge, publish,
+ * distribute, sublicense, and/or sell copies of the Software, and to
+ * permit persons to whom the Software is furnished to do so, subject to
+ * the following conditions:
+ *
+ * The above copyright notice and this permission notice shall be
+ * included in all copies or substantial portions of the Software.
+ *
+ * THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND,
+ * EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF
+ * MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE AND
+ * NONINFRINGEMENT. IN NO EVENT SHALL THE AUTHORS OR COPYRIGHT HOLDERS BE
+ * LIABLE FOR ANY CLAIM, DAMAGES OR OTHER LIABILITY, WHETHER IN AN ACTION
+ * OF CONTRACT, TORT OR OTHERWISE, ARISING FROM, OUT OF OR IN CONNECTION
+ * WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN THE SOFTWARE.
+ */
+#ifndef OPENSSL_COMPAT_H
+
+#define OPENSSL_101_API                                                        \
+  (!defined(LIBRESSL_VERSION_NUMBER) && OPENSSL_VERSION_NUMBER >= 0x10100005L)
+
+#endif // OPENSSL_COMPAT_H